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The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice.

Science translational medicine - 6 Nov 2024

Wallings Rebecca L, McFarland Karen, Staley Hannah A, Neighbarger Noelle, Schaake Susen, Brüggemann Norbert, Zittel Simone, Usnich Tatiana, Klein Christine, Sammler Esther M, Tansey Malú Gámez

Abstract excerpt

Age is the greatest risk factor for many neurodegenerative diseases, yet immune system aging, a contributor to neurodegeneration, is understudied. Genetic variation in the LRRK2 gene affects risk for both familial and sporadic Parkinson's disease (PD). The leucine-rich repeat kinase 2 (LRRK2) protein is implicated in peripheral immune cell signaling, but the effects of an aging immune system on LRRK2 function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39504353
DOI: 10.1126/scitranslmed.adl1535

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