LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

Abstract excerpt

While the contribution of inflammation in the pathological process leading to Parkinson’s disease (PD) is well established, a growing body of evidence supports a role for the long-lasting adaptive immune system in the disease. We showed that, in inflammatory conditions, the PD-proteins PINK1 and Parkin negatively regulate the presentation of mitochondrial antigens on MHC I molecules, a process referred to as MitAP...

Topics

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• Alzheimer's disease research and treatments
• Autophagy in Disease and Therapy
• Immune System
• Inflammation
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

32cb7535-1bc8-5675-a8e3-4177af7dfe49

DOI

10.1101/2023.06.14.545012