Article

Bidirectional disruption of Lrrk2 function drives T cell dysregulation and an exhaustion-like immune response

2026-08-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neurodegenerative diseases including Parkinson’s disease (PD) are increasingly associated with dysfunction in both central and peripheral immune systems. Pathogenic mutations in leucine-rich repeat kinase 2 ( LRRK2 ) represent a major cause of familial PD, while common polymorphisms are associated with inflammatory diseases. <h4>Methods</h4> Here, using immunophenotyping...

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Literature Corpus work: d0027d6e-34c0-58bf-a1f7-b374089666f5
DOI: 10.64898/2026.08.16.745139

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