Article

LRRK2 is recruited to phagosomes and co-recruits Rab8 and Rab10 in human pluripotent stem cell-derived macrophages

2019-09-25

Abstract excerpt

<h4>Summary</h4> The Parkinson’s disease-associated gene, LRRK2 , is also associated with immune disorders and infectious disease, and is expressed in immune subsets. Here, we characterise a platform for interrogating the expression and function of endogenous LRRK2 in authentic human phagocytes, using human induced Pluripotent Stem Cell-derived macrophages and microglia. Endogenous LRRK2 is expressed and upregul...

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Literature Corpus work: 67df030c-4fa3-5a1d-a19b-4e56147b09fb
DOI: 10.1101/779835

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