Article
Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex.
Nature communications - 17 Mar 2026
Meng Juan, Chen Cheng, Zhu Zhiyong, Sun Yongkang, Huang Yiming, Hu Kaijie, Fu Jiqiang, Wu Luyan, Li Ling, Bai Yiqin, Fei Tianyi, Liu Zhen, Li Chao, Shen Zhiming, Liu Longqi, Li Chengyu, Song Tao, Liu Cirong, Poo Muming, Liu Shiping, Lei Ying, Sun Yidi
Abstract excerpt
Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain, but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates. Here we performed single-nucleus Assay for Transposase-Accessible Chromatin followed by sequencing (snATAC-seq) for ~1.6 million cells from 142 cortical regions of two male cynomolgus...
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