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Article

Integrating the DNA damage and protein stress responses during cancer development and treatment.

The Journal of pathology - 1 Sept 2018

Gorgoulis Vassilis G, Pefani Dafni-Eleftheria, Pateras Ioannis S, Trougakos Ioannis P

Abstract excerpt

During evolution, cells have developed a wide spectrum of stress response modules to ensure homeostasis. The genome and proteome damage response pathways constitute the pillars of this interwoven 'defensive' network. Consequently, the deregulation of these pathways correlates with ageing and various pathophysiological states, including cancer. In the present review, we highlight: (1) the structure of the genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29756349
DOI: 10.1002/path.5097
PMCID: PMC6120562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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