Article

A stress response that allows highly mutated eukaryotic cells to survive and proliferate

2019-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Rapid mutation fuels the evolution of many cancers and pathogens. Much of the ensuing genetic variation is detrimental, but cells can survive by limiting the cost of accumulating mutation burden. We investigated this behavior by propagating hypermutating yeast lineages to create independent populations harboring thousands of distinct genetic variants. Mutation rate and spectrum remained unchange...

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Identifiers and source

Literature Corpus work: e2139879-a58b-59af-9fb2-1c45df410d8c
DOI: 10.1101/515460

Open publication

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