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Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types

7 Aug 2019

Abstract excerpt

Non-oncogene addiction (NOA) genes are essential for supporting the stress-burdened phenotype of tumours and thus vital for their survival. Although NOA genes are acknowledged to be potential drug targets, there has been no large-scale attempt to identify and characterise them as a group across cancer types. Here we provide the first method for the identification of conditional NOA genes and their rewired...

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PMID: 31396397
DOI: 10.1038/s41540-019-0104-5

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