Article

The aging genome exhibits organized vulnerability to somatic mutations

2026-05-22

Abstract excerpt

Somatic mutations accumulate throughout life and have been hypothesized to drive organismal decline. Yet whether these mutations are distributed randomly or whether cells shield their most critical components has remained unresolved. Here we analyze over a million somatic mutations across thirteen human tis-sues, finding that the aging genome exhibits organized vulnerability, captured by the existence of hypo-muta...

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Literature Corpus work: e6fbebfc-b969-5ca6-9b4f-a49150baf122
DOI: 10.64898/2026.05.21.726885

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