Article

Gains of 12p13.31 delay WNT-mediated initiation of hPSC differentiation and promote residual pluripotency in a cell cycle dependent manner

2021-05-23

Abstract excerpt

<h4>Summary</h4> Though gains of chromosome 12p13.31 are highly recurrent in hPSC, their impact on differentiation is poorly understood. We identify a reduction in differentiation capacity towards all three germ layers and a subpopulation of residual pluripotent cells that appear during hepatic specification. These cells form as a result of the overexpression of NANOG and GDF3, whereby NANOG as the primary driv...

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Literature Corpus work: e698bb42-3a82-5f16-9ebc-15d6f8178b0c
DOI: 10.1101/2021.05.22.445238

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