Article

A <i>Nanog</i> -dependent gene cluster initiates the specification of the pluripotent epiblast

2019-07-18

Abstract excerpt

<h4>Summary</h4> The epiblast (Epi) is the source of embryonic stem (ES) cells and all embryonic tissues. It differentiates alongside the primitive endoderm (PrE) in a randomly distributed “salt and pepper” pattern from the inner cell mass (ICM) during preimplantation of the mammalian embryo. NANOG and GATA6 are key regulators of this binary differentiation event, which is further modulated by heterogeneous FGF s...

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Literature Corpus work: d061b573-fb9d-5a71-8dba-24ba1de23074
DOI: 10.1101/707679

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