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Signalling pathways and transcriptional regulators orchestrating liver development and cancer

1 Sept 2021

Abstract excerpt

Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and...

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PMID: 34478514
DOI: 10.1242/dev.199814

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