Article

From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum

2024-11-15

Abstract excerpt

<h4>Summary</h4> Human central nervous system (CNS) development involves complex transitions from pluripotency to regionalised neural tissues. The early phases of this process are inaccessible in humans but can potentially be modelled in vitro using brain organoids, including to study neurodevelopmental disorders. However, current methods are based on post-implantation-like human pluripotent stem cells (hPSCs),...

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Literature Corpus work: f99e0c96-1b42-52e7-b087-e79eb1c4a446
DOI: 10.1101/2024.11.14.623407

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