Article

A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuum

2021-12-16

Abstract excerpt

<h4>Summary</h4> Basic helix-loop-helix genes, particularly proneural genes, are well-described triggers of cell differentiation, yet limited information exists on their dynamics, notably in human development. Here, we focus on Neurogenin 3 ( NEUROG3 ), which is crucial for pancreatic endocrine lineage initiation. Using a double reporter to monitor endogenous NEUROG3 transcription and protein expression in sing...

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Literature Corpus work: c5faa673-5550-5549-a499-ff4da05d9c0a
DOI: 10.1101/2021.12.15.472220

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