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Article

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Nature cell biology - 1 Jul 2017

Graf Urs, Casanova Elisa A, Wyck Sarah, Dalcher Damian, Gatti Marco, Vollenweider Eva, Okoniewski Michal J, Weber Fabienne A, Patel Sameera S, Schmid Marc W, Li Jiwen, Sharif Jafar, Wanner Guido A, Koseki Haruhiko, Wong Jiemin, Pelczar Pawel, Penengo Lorenza, Santoro Raffaella, Cinelli Paolo

Abstract excerpt

Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental ground state. Here we show that Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass (ICM) but...

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Source

Identifiers

PMID: 28604677
DOI: 10.1038/ncb3554

Genes

UHRF1
PRAME

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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