Article

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

2020-07-04

Abstract excerpt

<h4>Summary</h4> Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as transcriptomic profiling, to investigate how variability in signalling pathway activity between human embryonic stem cell lines affects their differentia...

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Literature Corpus work: 41f2222c-af72-5abd-b8f9-d9a507f93ca0
DOI: 10.1101/2020.07.03.186932

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