Article

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

2024-06-26

Abstract excerpt

<h4>Summary</h4> Human primordial germ cell-like cells (hPGCLCs) can be generated from pluripotent stem cells (PSCs) but the differentiation efficiency of female hPSCs is often lower than that of male hPSCs. Moreover, Klinefelter Syndrome (KS), a condition characterized by an extra X-chromosome in males, often presents the failure of germline specification and infertility. In this study, we investigate how X-link...

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Literature Corpus work: ebb555ce-9c5f-5bda-8062-ace162d2a7d4
DOI: 10.1101/2024.06.25.599839

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