Article

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC Interactions

2022-12-10

Abstract excerpt

T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges. This recognition of pathogens is driven by the interaction between membrane-bound T cell receptors (TCRs) and antigenic peptides presented on major histocompatibility complex (MHC) molecules. The formation of the TCR-peptide-MHC complex (TCR-pMHC) involves interac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e61263ee-689e-5a70-a235-b82aa3476ffc
DOI: 10.1101/2022.12.07.519507

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC InteractionsDOI 10.1101/2022.12.07.519507Read

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.Semantic proximity Read

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity.Semantic proximity Read

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificitySemantic proximity Read

CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCSemantic proximity Read

Somatic genetics of CDR3 control TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHCSemantic proximity Read

Coevolution of T‐cell receptors with MHC and non‐ MHC ligandsSemantic proximity Read

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Semantic proximity Read

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Semantic proximity Read

Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifsSemantic proximity Read

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twinsSemantic proximity Read

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selectionSemantic proximity Read

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read