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Article

Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

26 Dec 2019

Abstract excerpt

The T cell repertoire in each individual includes T cell receptors (TCRs) of enormous sequence diversity through the pairing of diverse TCR α- and β-chains, each generated by somatic recombination of paralogous gene segments. Whether the TCR repertoire contributes to susceptibility to infectious or autoimmune diseases in concert with disease-associated major histocompatibility complex (MHC) polymorphisms is...

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PMID: 31879353
DOI: 10.1073/pnas.1915008117

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