Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coevolution of T‐cell receptors with MHC and non‐ MHC ligands

18 Aug 2015

Abstract excerpt

The structure and amino acid diversity of the T-cell receptor (TCR), similar in nature to that of Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity to recognize antigen. Yet all currently defined native T cells expressing an α and β chain in their TCR can only sense antigen when presented in the context of a major histocompatibility complex (MHC) molecule. This MHC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26284470
DOI: 10.1111/imr.12327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coevolution of T‐cell receptors with MHC and non‐ MHC ligandsPMID 26284470Read ↗

Structural and functional evolution of the extracellular regions of T cell receptors.Semantic proximity Read ↗

The human T cell receptor in health and disease.Semantic proximity Read ↗

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteinsSemantic proximity Read ↗

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selectionSemantic proximity Read ↗

The Evolution and Structure of Atypical T Cell Receptors.Semantic proximity Read ↗

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Semantic proximity Read ↗

T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and CancerSemantic proximity Read ↗

Mechanisms of antigen receptor evolution.Semantic proximity Read ↗

MHC molecules as peptide receptors.Semantic proximity Read ↗

MHC structure and function – antigen presentation. Part 1.Semantic proximity Read ↗

The Conventional Nature of Non-MHC-Restricted T CellsSemantic proximity Read ↗

Receptor selection in B and T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.