Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry

23 Nov 2022

Abstract excerpt

Abstract MHC restriction, which describes the binding of TCRs from CD4+T cells to class II MHC proteins and TCRs from CD8+T cells to class I MHC proteins, is a hallmark of immunology. Seemingly rare TCRs that break this paradigm exist, but mechanistic insight into their behavior is lacking. TIL1383I is a prototypical class-mismatched TCR, cloned from a CD4+T cell but recognizing the tyrosinase tumor antigen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36424374
DOI: 10.1038/s41467-022-34896-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometryPMID 36424374Read ↗

TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide–HLA ComplexSemantic proximity Read ↗

T-cell receptor specificity maintained by altered thermodynamics.Semantic proximity Read ↗

TCR3d: The T cell receptor structural repertoire databaseSemantic proximity Read ↗

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read ↗

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read ↗

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.Semantic proximity Read ↗

T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4Semantic proximity Read ↗

Machine learning reveals a non-canonical mode of peptide binding to MHC class II molecules.Semantic proximity Read ↗

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.Semantic proximity Read ↗

Computational Design of the Affinity and Specificity of a Therapeutic T Cell ReceptorSemantic proximity Read ↗

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.Semantic proximity Read ↗

Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.