Article
A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2019
Reinink Peter, Shahine Adam, Gras Stephanie, Cheng Tan-Yun, Farquhar Rachel, Lopez Kattya, Suliman Sara A, Reijneveld Josephine F, Le Nours Jérôme, Tan Li Lynn, León Segundo R, Jimenez Judith, Calderon Roger, Lecca Leonid, Murray Megan B, Rossjohn Jamie, Moody D Branch, Van Rhijn Ildiko
Abstract excerpt
High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b present Ags to T cells with species-wide TCR motifs. CD1b tetramer studies and a survey of the 27 published CD1b-restricted TCRs demonstrated a TCR motif in humans...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.