Article

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

2025-02-10

Abstract excerpt

Thymic selection is a multi-stage process that establishes a T-cell immunity that is efficient in fighting diverse foreign pathogens, while not being self-reactive. During the process, T-cell receptor (TCR)α and β chains are rearranged to form a highly diverse set of heterodimers that are selected based on their affinity to peptides presented by major histocompatibility molecules (MHC) in the thymus. Here we emplo...

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Literature Corpus work: 57d97acd-6630-5db6-ba69-13bc8688bc46
DOI: 10.1101/2025.02.09.635277

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