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Article

Structure of the human K <sub>2P</sub> 13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

2024-06-27

Abstract excerpt

The halothane-inhibited K 2P leak potassium channel K 2P 13.1 (THIK-1) 1–3 is found in diverse cells 1,4 including neurons 1,5 and microglia 6–8 where it affects surveillance 6 , synaptic pruning 7 , phagocytosis 7 , and inflammasome-mediated interleukin-1β release 6,8,9 . As with many K 2P s 1,5,10–14 and other voltage-gated ion channel (VGIC) superfamily members 3,15,16 , polyunsaturated fatty acid...

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Literature Corpus work
e5ad5581-ea46-51e6-b276-edbe54210f32
DOI
10.1101/2024.06.26.600491
Open publication

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Structure of the human K <sub>2P</sub> 13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor siteDOI 10.1101/2024.06.26.600491
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