Structural evidence that a lipid plug controls K2P6.1(TWIK-2) function.

Abstract excerpt

Lipids are integral to ion channel function yet delineating mechanisms by which they affect function remains challenging. Within the K2P family of leak potassium channels, observation of tubular densities interpreted as alkyl chains occupying lateral fenestrations linking the pore and bilayer raised the possibility that lipid access from the bilayer acts as a regulatory mechanism. Here, we present cryo-electron...

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