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Article

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.

The Journal of biological chemistry - 10 Oct 2014

Blin Sandy, Chatelain Franck C, Feliciangeli Sylvain, Kang Dawon, Lesage Florian, Bichet Delphine

Abstract excerpt

Despite a high level of sequence homology, tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents, whereas THIK2 is silent. This lack of activity is due to a unique combination of intracellular retention and weak basal activity in the plasma membrane. Here, we designed THIK subunits containing dominant negative mutations (THIK1(DN) and THIK2(DN)). THIK2(DN) mutant inhibits...

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Identifiers

PMID: 25148687
DOI: 10.1074/jbc.M114.600437
PMCID: PMC4192476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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