Article

Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

2020-06-18

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes three putative ion channels: E, 8a, and 3a 1,2 . 3a is expressed in SARS patient tissue and anti-3a antibodies are observed in patient plasma 3–6 . 3a has been implicated in viral release 7 , inhibition of autophagy 8 , inflammasome activation 9 , and cell death 10...

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Literature Corpus work: d4843df9-08c2-5241-9a94-22b5835646aa
DOI: 10.1101/2020.06.17.156554

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