Article

Structural basis for proton inhibition of the two-pore domain K <sup>+</sup> channel TASK-1

2025-04-26

Abstract excerpt

<h4>Summary</h4> TASK-1 is a pH-sensitive two-pore domain K + channel inhibited by external protons. TASK-1 is widely expressed, including in cardiomyocytes and chemosensitive neurons in the brain. Altered channel expression and activity are implicated in diseases including atrial fibrillation, pulmonary arterial hypertension, and developmental delay with sleep apnea. Structures of TASK-1 have been captured with...

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Literature Corpus work: 561d3e18-335b-58b8-a657-313b1558ee20
DOI: 10.1101/2025.04.23.650279

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