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Article

A lower X-gate in TASK channels traps inhibitors within the vestibule.

Nature - 1 Jun 2020

Rödström Karin E J, Kiper Aytuğ K, Zhang Wei, Rinné Susanne, Pike Ashley C W, Goldstein Matthias, Conrad Linus J, Delbeck Martina, Hahn Michael G, Meier Heinrich, Platzk Magdalena, Quigley Andrew, Speedman David, Shrestha Leela, Mukhopadhyay Shubhashish M M, Burgess-Brown Nicola A, Tucker Stephen J, Müller Thomas, Decher Niels, Carpenter Elisabeth P

Abstract excerpt

TWIK-related acid-sensitive potassium (TASK) channels-members of the two pore domain potassium (K2P) channel family-are found in neurons1, cardiomyocytes2-4 and vascular smooth muscle cells5, where they are involved in the regulation of heart rate6, pulmonary artery tone5,7, sleep/wake cycles8 and responses to volatile anaesthetics8-11. K2P channels regulate the resting membrane potential, providing background K+...

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Anesthetics
Crystallography, X-Ray
Electric Conductivity
Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Patch-Clamp Techniques

Potassium Channels, Tandem Pore Domain

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PMID: 32499642
DOI: 10.1038/s41586-020-2250-8

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A lower X-gate in TASK channels traps inhibitors within the vestibule.PMID 32499642Read ↗

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