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Article

Gating of human TRPV3 in a lipid bilayer.

Nature structural & molecular biology - 1 Jul 2020

Deng Zengqin, Maksaev Grigory, Rau Michael, Xie Zili, Hu Hongzhen, Fitzpatrick James A J, Yuan Peng

Abstract excerpt

The transient receptor potential cation channel subfamily V member 3 (TRPV3) channel plays a critical role in skin physiology, and mutations in TRPV3 result in the development of a congenital skin disorder, Olmsted syndrome. Here we describe multiple cryo-electron microscopy structures of human TRPV3 reconstituted into lipid nanodiscs, representing distinct functional states during the gating cycle. The...

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Identifiers

PMID: 32572252
DOI: 10.1038/s41594-020-0428-2
PMCID: PMC7354234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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