Article

Structure of the receptor-activated human TRPC6 ion channel

2018-03-15

Abstract excerpt

TRPC6 is a receptor-activated nonselective cation channel that belongs to the family of canonical transient receptor potential (TRPC) channels. It is activated by diacylglycerol, a lipid second messenger. TRPC6 is involved in many physiological processes and implicated in human genetic diseases. Here we present the structure of human TRPC6 homotetramer in complex with a newly identified high affinity inhibitor BTD...

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Literature Corpus work: f2cdc7a9-e50d-5859-b14b-f27fae008e78
DOI: 10.1101/282814

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