Article

Physical basis for distinct basal and mechanically-gated activity of the human K <sup>+</sup> channel TRAAK

2021-06-06

Abstract excerpt

<h4>Summary</h4> TRAAK is a mechanosensitive two-pore domain K + (K2P) channel localized to nodes of Ranvier in myelinated neurons. TRAAK deletion in mice results in mechanical and thermal allodynia and gain-of-function mutations cause the human neurodevelopmental disorder FHEIG. TRAAK displays basal and stimulus-gated activities typical of K2Ps, but the mechanistic and structural differences between these modes...

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Identifiers and source

Literature Corpus work: 3de97e11-d597-59a6-bf51-419c63bef79c
DOI: 10.1101/2021.06.04.447000

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