Article

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs

2019-10-14

Abstract excerpt

Cation-chloride-cotransporters (CCCs) catalyze transport of Cl − with K + and/or Na + across cellular membranes. CCCs play roles in volume regulation, neural development and function, audition, blood pressure regulation, and renal function. CCCs are targets of drugs including loop diuretics and their disruption is implicated in pathophysiologies including epilepsy, hearing loss, and the genetic disorders Anderm...

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Literature Corpus work: 89ac6132-7b9d-5fab-823b-cfd60ae7b162
DOI: 10.1101/805267

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