Article

7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas

2024-09-26

Abstract excerpt

<title>Abstract</title> <bold>Background</bold> Immune checkpoint inhibitors (ICIs) present clinical benefits in many cancer patients but invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor. The lack of ICIs efficacy in GBM is attributed to the accumulation of tumor-reprogrammed myeloid cells (GAMs) that create the “cold” immunosuppressive tumor microenvironment (TME), impedin...

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Literature Corpus work: e5a316af-4aec-51e4-825c-030007d48468
DOI: 10.21203/rs.3.rs-5116200/v1

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