Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

doi:10.1016/j.immuni.2026.06.024

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Article

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

Immunity - 11 Aug 2026

Qian Jiawen, Wang Chen, Zhang Yi, Li Congwen, Zeng Yingying, Zhang Shuangyan, Gao Fei, Zhu Yiwen, Cai Peiliang, Zhang Zhongyuan, Hu Yanan, Yu Xiaotong, Kloeckner Benoit, Moreira Marco, Wang Yuedi, Wang Bo, Zhao Chujun Julia, Zhang Dan, Chen Xi, Liu Shang, Coutansais Auriane, Zhuang Huangmijia, Liu Ronghua, Luo Feifei, Wu Liang, Pasqualini Claudia, Chen Yihua, Li Xinyan, Lu Mingfang, Li Ziyi, Guo Wei, Chakarov Svetoslav, Liu Zhaoyuan, Su Bing, Zhao Rui, Chu Yiwei, Ginhoux Florent

Abstract excerpt

Malignant gliomas are lethal brain tumors characterized by profound local immunosuppression and a radically remodeled myeloid landscape. Although these tumors mobilize resident microglia and infiltrating monocyte-derived macrophages, the mechanisms governing their phenotypic convergence and diversification remain elusive. Here, we integrated single-cell profiling and spatial transcriptomics of glioma-associated...

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PMID: 42497861
DOI: 10.1016/j.immuni.2026.06.024

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