Article

Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcome

2024-08-08

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitors (ICI) presented clinical benefits in many cancer patients but invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor. Lack of ICI efficacy in GBM is attributed to the accumulation of immunosuppressive myeloid cells that create the “cold” tumor microenvironment (TME) impeding infiltration and activation of effector T cells. We developed...

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Literature Corpus work: 63c0b8c0-3145-5cc3-9f96-a10bf3075a94
DOI: 10.1101/2024.08.06.606798

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