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A dual pronged approach to cancer immune exclusion: tumor-derived LAIR-1 simultaneously drives fibrosis and blocks immune recruitment in glioma

2026-08-05

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma is among the most lethal human malignancies. Immune-based therapies have failed due to a strong immunosuppressive tumor microenvironment (TME)1. We uncovered that LAIR-12 expressed by tumor cells simultaneously drives TME fibrosis and inhibits migration of immune cells to brain tumors, thus achieving powerful immune exclusion3. We demonstrate that glioma-cell-specific LAIR-...

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Literature Corpus work
b2352592-a70c-5ea5-88aa-98429b3f3775
DOI
10.21203/rs.3.rs-10472790/v1
Open publication

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A dual pronged approach to cancer immune exclusion: tumor-derived LAIR-1 simultaneously drives fibrosis and blocks immune recruitment in gliomaDOI 10.21203/rs.3.rs-10472790/v1
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