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Article

SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment.

Cell death & disease - 15 Sept 2024

Snacel-Fazy Emmanuel, Soubéran Aurélie, Grange Magali, Joseph Kevin, Colin Carole, Morando Philippe, Luche Hervé, Pagano Alessandra, Brustlein Sophie, Debarbieux Franck, Toutain Soline, Siret Carole, van de Pavert Serge A, Rougon Geneviève, Figarella-Branger Dominique, Ravi Vidhya Madapusi, Tabouret Emeline, Tchoghandjian Aurélie

Abstract excerpt

Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous immune cells that can be immune-supportive or tumor-supportive depending of the microenvironment. TAMs are the most abundant immune cells in glioblastoma (GB), and play a key role in immunosuppression. Therefore, TAMs reprogramming toward immune-supportive cells is a promising strategy to overcome immunosuppression. By leveraging...

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Identifiers

PMID: 39278921
DOI: 10.1038/s41419-024-07056-z
PMCID: PMC11402972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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