Article

Single-cell profiling and zebrafish avatars reveal <i>LGALS1</i> as immunomodulating target in glioblastoma

2023-05-01

Abstract excerpt

Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive microenvironment are key factors contributing to the poor response rates of current therapeutic approaches. GBM-associated macrophages (GAMs) often exhibit immunosuppressive features that promote tumor progression. However, their dynamic interactions with...

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Literature Corpus work: 2e0f8cf2-8bbc-507d-aed7-43df294b4e3b
DOI: 10.1101/2023.04.27.538517

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