Article

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.

2018-09-18

Abstract excerpt

Imbalance in the level of the pyrimidine degradation products dihydrouracil and dihydrothymine is associated with cellular transformation and cancer progression. Dihydropyrimidines are degraded by dihydropyrimidinase (DHP), a zinc metalloenzyme that is upregulated in solid tumors but not in the corresponding normal tissues. How dihydropyrimidine metabolites affect cellular phenotypes remains elusive. Here we show...

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Literature Corpus work: e4f6feae-f4a5-51c2-a084-6e637676eb61
DOI: 10.1101/420893

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