Article

DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status

2019-09-13

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication stress is a predominant cause of genome instability, a driver of tumorigenesis and malignant progression. Nucleoside analog-type chemotherapeutic drugs introduce DNA damage and exacerbate DNA replication stress in tumor cells. However, the mechanisms underlying tumor cytotoxicity triggered by the drugs are not fully understood. Here, we show that the fluorinated thymidine analog...

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Literature Corpus work: df7ca4c4-2731-503d-ad17-0ef9531f1144
DOI: 10.1101/764522

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