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Article

The Role of dUTPase and Uracil-DNA Repair in Cancer Chemotherapy

1 Dec 2001

Abstract excerpt

Thymidylate metabolism is an important target for chemotherapeutic agents that combat a variety of neoplastic diseases including head and neck, breast and gastrointestinal cancers. Therapeutic strategies applied to this pathway target the thymidylate synthase (TS) reaction that catalyzes the reductive methylation of deoxyuridylate (dUMP) to form thymidylate (TMP). This reaction represents the sole de novo source...

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PMID: 12374095
DOI: 10.2174/1389203013380991

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