Article

Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden

2022-08-05

Abstract excerpt

<h4>Summary</h4> Oncogenic mutations in the metabolic enzyme isocitrate dehydrogenase 1 and 2 (IDH1/2) have been found in a number of liquid and solid tumors. Their pathogenic mechanism of action involves production of 2-hydroxyglutarate (2HG), an oncometabolite that acts in part by inhibiting members of a family of dioxygenases that modulate chromatin dynamics. Recent work has suggested that mutant IDH (mIDH) an...

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Literature Corpus work: 3a1b685e-f98b-565e-b884-714f214d229d
DOI: 10.1101/2022.08.04.502834

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