Article
Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.
Molecular cell - 17 Nov 2016
Vaz Bruno, Popovic Marta, Newman Joseph A, Fielden John, Aitkenhead Hazel, Halder Swagata, Singh Abhay Narayan, Vendrell Iolanda, Fischer Roman, Torrecilla Ignacio, Drobnitzky Neele, Freire Raimundo, Amor David J, Lockhart Paul J, Kessler Benedikt M, McKenna Gillies W, Gileadi Opher, Ramadan Kristijan
Abstract excerpt
The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in cells, either as a consequence of metabolism or exogenous agents, but the mechanism of DPC repair is not completely understood. Here, we characterize SPRTN as a specialized DNA-dependent and DNA replication-coupled metalloprotease for DPC repair. SPRTN...
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