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Article

Amplifying tumour-specific replication lesions by DNA repair inhibitors - a new era in targeted cancer therapy.

European journal of cancer (Oxford, England : 1990) - 1 May 2008

Helleday Thomas

Abstract excerpt

Many anti-cancer drugs used in the clinic today damage DNA, resulting in cell death either directly or following DNA replication. Many anti-cancer drugs are exclusively toxic to replicating cells and toxic lesions are formed when a replication fork encounters a damaged DNA template. Recent work shows that replication lesions, similar to those produced during anti-cancer therapy, are commonly associated with...

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Identifiers

PMID: 18374562
DOI: 10.1016/j.ejca.2008.02.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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