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Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugs

2021-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Chronic DNA replication stress and genome instability are two hallmarks of cancer that fuel oncogenesis and tumor diversity. Therapeutic approaches aimed to leverage tumor-specific replication stress to intolerable levels or to expose vulnerabilities for synthetic lethality purposes have recently gained momentum, especially for pancreatic cancer, a disease with no cure. However, the current know...

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Identifiers and source

Literature Corpus work
4c230ca2-390b-5bad-96cd-e822e5a0d78a
DOI
10.1101/2021.10.23.465566
Open publication

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