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E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network

1 Jul 2024

Abstract excerpt

Various lines of investigation support a signaling interphase shared by receptor tyrosine kinases and the DNA damage response. However, the underlying network nodes and their contribution to the maintenance of DNA integrity remain unknown. We explored MET-related metabolic pathways in which interruption compromises proper resolution of DNA damage. Discovery metabolomics combined with transcriptomics identified...

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PMID: 38957115
DOI: 10.1158/2767-9764.crc-23-0370

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