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Article

Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination.

Molecular cell - 6 Jul 2023

Schvartzman Juan-Manuel, Forsyth Grace, Walch Henry, Chatila Walid, Taglialatela Angelo, Lee Brian J, Zhu Xiaolu, Gershik Steven, Cimino Francesco V, Santella Anthony, Menghrajani Kamal, Ciccia Alberto, Koche Richard, Sánchez-Vega Francisco, Zha Shan, Thompson Craig B

Abstract excerpt

Oncogenic mutations in isocitrate dehydrogenases 1 and 2 (IDH1/2) produce 2-hydroxyglutarate (2HG), which inhibits dioxygenases that modulate chromatin dynamics. The effects of 2HG have been reported to sensitize IDH tumors to poly-(ADP-ribose) polymerase (PARP) inhibitors. However, unlike PARP-inhibitor-sensitive BRCA1/2 tumors, which exhibit impaired homologous recombination, IDH-mutant tumors have a silent...

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Identifiers

PMID: 37311462
DOI: 10.1016/j.molcel.2023.05.026
PMCID: PMC10845120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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