Article

Advancing Transcription Factor Binding Site Prediction Using DNA Breathing Dynamics and Sequence Transformers via Cross Attention

2024-01-20

Abstract excerpt

Understanding the impact of genomic variants on transcription factor binding and gene regulation remains a key area of research, with implications for unraveling the complex mechanisms underlying various functional effects. Our study delves into the role of DNA’s biophysical properties, including thermodynamic stability, shape, and flexibility in transcription factor (TF) binding. We developed a multi-modal deep l...

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Literature Corpus work: 58c8bf32-9228-5e3d-a4e3-fe1c27da3829
DOI: 10.1101/2024.01.16.575935

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