Article

Chromatin information content landscapes inform transcription factor and DNA interactions

2019-09-23

Abstract excerpt

Interactions between transcription factors (TFs) and chromatin are fundamental to genome organization and regulation and, ultimately, cell state. Here, we use information theory to measure signatures of TF-chromatin interactions encoded in the patterns of the accessible genome, which we call chromatin information enrichment (CIE). We calculate CIE for hundreds of TF motifs across human tissues and identify two cla...

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Identifiers and source

Literature Corpus work: 878add31-d293-58d0-98a8-f45932f78646
DOI: 10.1101/777532

Open publication

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